Fatu and his wife Talisua Fuavai-Fatu have five children. He rubs his nose twice en route to the ring to tell his children that he loves them. Fatu is a member of the famous Anoa'i wrestling family. He is the father of the Samoan Soldiers; his twin sons Jonathan Solofa and Joshua Sammy . The pair are currently known as Jimmy and Jey Uso on WWE's SmackDown brand. Fatu also has a daughter Thavana Monalisa and two younger sons: Jeremiah Peniata and Joseph . Fatu is the nephew of Sika Anoa'i and Afa Anoa'i, known as the Wild Samoans. is also the brother of the late Eddie Fatu and Sam Fatu and cousin of Dwayne Johnson Rodney Anoa'i , Samula Anoa'i , and Matt Anoa'i .
On April 27, 2008, Fatu's mother Vera died after a seven-year battle with cancer.
Fatu's brother Eddie "Umaga" Fatu died of a heart attack on December 4, 2009.